Junran Zhang; Kaiyan Shao; Shuguo Yang; Qinghua Ma
Volume 23, Issue 9 , 2021
Abstract
Background: The present study aimed to investigate the relationship between creatine kinase (CK) and major bleeding in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) during hospitalization.
Objectives: The predictive value of CK was also analyzed for the patients during treatment.
Methods: ...
Read More
Background: The present study aimed to investigate the relationship between creatine kinase (CK) and major bleeding in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) during hospitalization.
Objectives: The predictive value of CK was also analyzed for the patients during treatment.
Methods: A total of 1469 patients with NSTE-ACS, including 1024 and 445 patients with unstable angina pectoris and non-ST-segment elevation myocardial infarction, respectively, were admitted to Linyi Central Hospital, Linyi, China from January 2017 to December 2019. Plasma CK and hemoglobin concentrations were measured after admission. The patients were divided into the major bleeding (n=31) and non-major bleeding (n=1438) groups according to Thrombolysis in Myocardial Ischemia bleeding classification standard, and they received routine treatment.
Results: Major bleeding occurred in 31 of 1469 (2.11%) patients with NSTE-ACS during the treatment period. The value of CK in the major bleeding group was higher than that of the non-major bleeding group (P<0.001). CK was divided into groups Q1- Q4 according to the quartile, and the incidence of major bleeding was higher in group Q4 than that of the other three groups (P<0.001). Plasma CK was positively correlated with major bleeding in patients with NSTE-ACS (r=0.59, P<0.001). Receiver operating characteristic curve analysis indicated that the area below the curve of baseline CK value was 0.793 (SE=0.062, P=0.001, 95?CI 0.711-0.872) in patients with NSTE-ACS during treatment.
Conclusion: CK was associated with major bleeding in patients with NSTE-ACS.
Junran Zhang; Kaiyan Shao; Shuguo Yang; Qinghua Ma
Volume 22, Issue 8 , 2020
Abstract
Background: Coronary heart disease (CHD) is myocardial ischemia caused by coronary atherosclerosis and stenosis.
Objectives: This study aimed to investigate the relationship of CHD with glycated albumin (GA), glycosylated hemoglobin (HbA 1c), glucose (Glu), homocysteine (Hcy), triglyceride (TG), and ...
Read More
Background: Coronary heart disease (CHD) is myocardial ischemia caused by coronary atherosclerosis and stenosis.
Objectives: This study aimed to investigate the relationship of CHD with glycated albumin (GA), glycosylated hemoglobin (HbA 1c), glucose (Glu), homocysteine (Hcy), triglyceride (TG), and apolipop protein A (apoA) levels in elderly patients with type 2 diabetes mellitus (T2DM). Moreover, it was attempted to predict which changes had a significant correlation with the occurrence of CHD in these biochemical indicators.
Methods: This clinical cohort study included a total of 472 patients admitted to our hospital from June 2018 to June 2019. They were then divided into three groups of concurrent (n=168, T2DM complicated with CHD), DM (n=148, T2DM alone), and control (n=156, healthy individuals).
Results: There were significant differences between the disease group (i.e., DM and concurrent groups) and control group in terms of GA (P=0.013, 28.58±8.01 vs. 15.77±1.44), HbA 1c (P=0.022, 9.5±1.5 vs. 5.5±0.5), Glu (P=0.012, 8.54±2.23 vs. 4.12±0.39), Hcy (P=0.031, 11.16±3.28 vs. 5.03±2.87), TG (P=0.021, 1.83±0.49 vs. 0.84±0.18), and apoA (P=0.031, 1.10±0.12 vs. 1.30±0.18).
Moreover, GA (P=0.025, 27.14±6.34 vs. 28.58±8.01; concurrent group vs. DM group), HbA 1c (P=0.033, 8.3±1.2 vs. 9.5±1.5; concurrent group vs. DM group), Glu (P=0.019, 8.62±3.56 vs. 8.54±2.23; concurrent group vs. DM group), Hcy (P=0.031, 17.56±6.36 vs. 11.16±3.28; concurrent group vs. DM group), total cholesterol ([TC); P=0.022, 3.06±0.20 vs. 3.69±0.29; concurrent group vs. DM group), and low-density lipoprotein ([LDL); P=0.037, 2.57±1.02 vs. 3.40±1.17; concurrent group vs. DM group) in disease group (DM group and concurrent group) were higher than those in the control group; however, apoA (P=0.023, 0.95±0.12 vs. 1.10±0.12; concurrent group vs. DM group) in disease group was lower than that in the control group. Furthermore, there were significant differences between the disease and control groups in terms of GA, HbA 1c, Glu, Hcy, TC, LDL, and apoA (P<0.05). Pearson correlation analysis between DM and concurrent groups was performed on the clinical parameters with statistical differences, and GA was highly correlated with HbA 1c and Glu (P<0.01).
Conclusion: High-risk patient screening with high levels of GA, Hcy, and apoA in elderly patients with T2DM can not only improve the symptoms of patients with targeted treatment but also reduce the incidence of CHD by timely intervention, which is of great significance to improve the quality of life of patients.
